Tuesday, May 7, 2019

IMMUNOLOGY OF HIV INFECTIONS part 22




The real problem with the monkey models is that experiments to evaluate vaccine efficacy requires challenging the vaccinated animals with high doses of virus to get 100% infection, that is, 10(3)-10(5) TCID50 equivalent to 5x10(7) SIV RNA copies/ml. This is in marked contrast to natural exposure to HIV in humans wherein the doses of 10(3) HIV RNA copies/ml of seminal plasma have been reported. However, these results are quite different in mucosal challenge, wherein reported low doses (10-30 TCID50) with SIV results in the same viral and immunological kinetics of infection as high-dose challenges. Thus, this new type of mucosal challenge might change the results of preclinical vaccine efficacy studies in the future.

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