Immunological aspects of allergy and anaphylaxis part 38

Within minutes of allergen inhalation in sensitized individuals, IgE antibodies fixed to mast cells and basophils trigger release of acute preformed mediators such as histamine and tryptase in the early-phase response. Shortly afterward, de novo generation of mediators, including cysteinyl-leukotrienes (LTC4, LTD5 and LTE4) as well as prostaglandine D2 (PGD2) occurs. These substances cause a pronounced  inflammatory  response leading  to the typical symptoms of paroxysmal sneezing, nasal pruritis and congestion, clear rhinorrhea, and palatal itching.