CASE I. AUTOIMMUNE HEMOLYTIC ANEMIA (AIHA)
A. TYPE II AUTOIMMUNE REACTION
COMMENT:
AIHA can occur in a variety of circumstances, including neoplastic diseases (most often lymphomas), connective tissue diseases (such as SLE), and infections (viral, bacterial, or mycoplasma). Or it may be drug induced (classically penicillin). The initial treatment is to diagnose and treat the underlying cause or remove offending agents. If this is not possible, corticosteroid such as prednisone are often used. If patients do not respond, then consideration is given to the use of cytotoxic drugs (eg azathioprine or vincristine) or splenectomy.
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