Examples of type IV autoimmune reactions include insulin-dependent diabetes mellitus (pancreatic antigens, such as glutamic acid dehydrogenase, insulin, and other islet cell antigens are recognized), multiple sclerosis (unidentified components of myelin are recognized), experimental autoimmune encephalomyelitis (an animal model of multiple sclerosis in which myelin basic protein is recognized), and Hashimoto's thyroiditis (thyroid antigens such as thyroid peroxidase and thyroglobulin are recognized).
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