Multiple sclerosis is a chronic disabling disease of the central nervous system that results from the effects of unknown enviromental risk factors acting in genetically susceptible individuals. Susceptibility in multiple sclerosis been linked mainly to the HLA-DRB1 locus, with the HLA-DR15 haplotype (DRB1*1501-DQA1*0102-DQB1*0602-DRB5*0101) dominating multiple sclerosis risk in Caucasians. Although genes in the HLA-II regions, particularly DRB1*1501, DQA1*0102-DQB1*0602, are tight in linkage disequilibrium and gene, candidate studies identified the DRB1*1501 allele as the primary risk factor in multiple sclerosis. Many genetic and immune-functional studies have indicated DRB1*1501 as a primary risk factor in multiple sclerosis, while only some functional studies suggested a disease-modifying role for the DRB5*01 or DQB1*06 alleles.
No comments:
Post a Comment