In some cases, HLA genes are co-located on chromosome 6 such that they are inevitably inherited "en bloc" and are linked as are the HLA-DRB1 and DRB3-5 genes. For example, the -DR15:01 allele is always found with the -DRB5 gene. In some cases, there is conserved inheritance of alleles on the same chromosome constituting a haplotype. HLA genes and their protein allotypes can sometimes be identified on commonly recognized haplotypes.
No comments:
Post a Comment