Despite the temptation to think of HLA as "transplantation antigens", HLA antigens are not present on tissues simply to confound transplant surgeons. The most important function of HLA molecule is in induction, regulation of immune responses and the selection of the T cell repertoir. A clinician's attention is normally drawn to a system only when it malfunction. The HLA system is no exception in this regard, but in contrast to other systems, it also arouses interest when it functions well - too well, in fact.
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