Another advantage is that MSCs can take up and retain introduced genes, a property that can be exploited for the delivery of clinically beneficial proteins to targeted locations. MSCs are also amenable to cryo-preservation, allowing their future use in "off-the-shelf" therapies. Animal studies seeking to reconstitute or repair damaged cartilage, bone, muscle, heart muscle and tendon using MSCs have shown great promise raising the possibility that they might one day be used for repairing tissue damaged by autoimmune attack. Indeed, cell therapy using MSCs can prevent damage to the joints in collagen-induced arthritis and also can ameliorate end-organ damage in EAE and murine lupus.
No comments:
Post a Comment