Similarly, such a mechanism could also promote the origin of M-CLL. As already mentioned, IgVH gene mutations can occur without T-cell help in marginal zones outside of GCs. Because mutations can sometimes favor autoreactivity, such autoreactive B cells would become expanded. However, expansion would stop if IgV gene mutations alter BCR structure in such a way that antigen binding is no longer sufficient to induce B-cell signalling.
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