CHARACTERIZING THE HETEROGENEITY OF B-CLL BY MOLECULAR AND CLINICAL SUBTYPES
Based on their mutation status, B-CLL patients can be divided into two groups those whose B-CLL cells use unmutated IgVHgenes (U-CLL) and those B_CLL cells use mutated IgVH genes (M-CLL). Initially, it was believed that the two types of B-CLL cells could be generated by vigin and memory cells, rsepectively, although, as we shall discuss there is now evidence that both B-CLL subtypes derive from (auto) antigen -experienced B cells.
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