Certain types of urticaria may be brought on by physical disruption of mast cells by either cold, scratching, or pressure. There is no IgE mediation of these reactions, unlike those from foods, but histamine release from the cells is common to all. Swelling of the skin due to damage to small blood vessels causes burning and pain of the areas involved and may last for several days. The burning and pain are unrelated to allergies or physical mast cell disruption. These might typically be related to a systemic disorder, and precipitating IgG autoantibodies against C1q may be found along with other organ involvement. Fevers, bone pain, and arthralgia may also occur along with the skin involvement.
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