Immunological aspects of infections part 8

Perhaps the best example of an incomplete recognition by the TLR system is a gram negative bacterial infection in the C3H/HeJ mouse. As few as two colony-forming units of Salmonella thypimurium can kill this mouse. Further exploration of this extraordinary virulence revealed that the mouse harbored a point mutation (P712H) in the TLR4, which results in defective signal transduction in response to LPS and a heightened susceptibility to gram-negative infection.