Although atopy has a strong genetic component, environtmental factors best explain the recent global trend toward increased prevalence of allergic disease. Predictive factors include the following:
- decreased exposure to infectious disease during early childhood
- changes in diet
- higher levels of allergen exposure
- increased environtmental pollution
Of these factors, variances in exposure to infectious disease appear to have the greatest correlation with atopy. Epidemioligical studies point out a negative association between atopic disease in children and a history of measles or hepatitis A virus infection. It is hypothesized that infections such as these tilt the production of cytokines toward interferon gamma (IFN-γ) and the TH1 cytokines, thereby decreasing production of TH2 allergic cytokines such as IL-4. This theory's attractiveness may be its ability to explain the global increase in atopy due to decreased infection rates in Westernized regions with aggressive vaccination programs.
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Emilio Aguinaldo College (EAC) was founded in 1951 under the name of Marian School of Midwifery. The Emilio Aguinaldo College of Medicine was established on July 23, 2001, and it has two campuses in Manila city and greater Manila. It is approved by Commission of Higher Education (CHED) Philippines.
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University of Perpetual Help System Dalta (UPHSD), is a co-education Institution of higher learning located in Las Pinas City, Metro Manila, Philippines. founded in 1975 by Dr. (Brigadier) Antonio Tamayo, Dr. Daisy Tamayo, and Ernesto Crisostomo as Perpetual Help College of Rizal (PHCR). Las Pinas near Metro Manila is the main campus. It has nine campuses offering over 70 courses in 20 colleges.
The Davao Medical School Foundation, Inc. (DMSFI) was established in July 1976 in response to the recognition of the lack of doctors serving rural communities and lack of specialist in urban centres of Mindanao. Its College of Medicine was thus the first such college to be set up in Mindanao and is dedicated to providing medical education and training of the highest order, leading to the provision of effective medical care in both rural and urban communities.
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