Magone and colleagues applied such a model to evaluate the role of various cytokines, including IL-4, IFN-γ, and IL-12, in the early and late phases of ocular allergy using knockout (KO) mice and neutralizing antibodies. In this model, multiple mice experimental groups, including:
- ragweed-sensitized wild type
- IL-4KO type
- IL-12KO type
- IFN-γKO type
- anti-IL-12/mAb-treated
- anti-IFN-γ m-Ab-treated mice were challenged with ragweed allergen ten days after immunization.
An additional group received recombinant murine IL-12. They found the anti IL-12 antibody-treated and IL-12KO type mice failed to show allergic cellular infiltration into the conjunctiva. IFN-γKO type mice, however, had a significantly stronger immediate-type hypersensitivity reactions and prolonged allergic cellular infiltration after ragweed exposure. Overall, their data provided evidence of IL-12 as an inducer of the late phase of ocular allergy. Additionally, the data suggest IFN-γ as a limiting factor of the late phase and a potential therapeutic cytokine in the prevention of chronic allergic disease. Further research is aimed at preventing initial sensitization to allergens.
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Emilio Aguinaldo College (EAC) was founded in 1951 under the name of Marian School of Midwifery. The Emilio Aguinaldo College of Medicine was established on July 23, 2001, and it has two campuses in Manila city and greater Manila. It is approved by Commission of Higher Education (CHED) Philippines.
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University of Perpetual Help System Dalta (UPHSD), is a co-education Institution of higher learning located in Las Pinas City, Metro Manila, Philippines. founded in 1975 by Dr. (Brigadier) Antonio Tamayo, Dr. Daisy Tamayo, and Ernesto Crisostomo as Perpetual Help College of Rizal (PHCR). Las Pinas near Metro Manila is the main campus. It has nine campuses offering over 70 courses in 20 colleges.
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