Within minutes of allergen inhalation in sensitized individuals, IgE antibodies fixed to mast cells and basophils trigger release of acute preformed mediators such as histamine and tryptase in the early-phase response. Shortly afterward, de novo generation of mediators, including cysteinyl-leukotrienes (LTC4, LTD5 and LTE4) as well as prostaglandine D2 (PGD2) occurs. These substances cause a pronounced inflammatory response leading to the typical symptoms of paroxysmal sneezing, nasal pruritis and congestion, clear rhinorrhea, and palatal itching.
No comments:
Post a Comment