Cardiovascular disease can deprive heart tissue of oxygen, thereby killing cardiac muscle (cardiomyocytes). This loss triggers a cascade of detrimental events, including formation of scar tissue, an overload of blood flow and pressure capacity, the overstretching of viable cardiac cells attempting to sustain cardiac output, leading to heart failure, and eventual death. Restoring damaged heart muscle tissue, through repair of regeneration, is therefore a potentially new strategy to treat heart failure.
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