In hematopoietic stem cell transplantation, stem cells are harvested from the patient or donor and, following leukemia treatment, are transplanted back into the patient to restore their blood and immune systems. In the case of stem cell-based skin or corneal grafting, skin or limbal stem cells are obtained from the patient, and then grown in the lab to produce sheets of cells sufficient to cover the burn or wound area. These applications exemplify two different approaches to transplanting tissue stem cells: one requires expanding cell numbers through lab culture, while the other does not.
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