Tissue stem cells have been used therapeutically for many years in the contexts of hematopoietic stem cell transplantation, a vital component in the sucessful therapy of many types of blood cancer; stem cell-based skin grafting (Green et al., 1979, Green, 1989), which can save the lives of patients with extensive third-degree burns; and limbal stem cell grafting, which can restore sight to patients with impaired vision caused by corneal damage (Rama et al., 2010).
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