Chronic kidney disease and its complication part 1

Chronic kidney disease and its complication:

ACIDOSIS

People with eGFR < 30 ml.min/1.73m2 are at increased risk of metabolic acidosis. The main factor is decreased renal acid excretion compounded by a reduction in bicarbonat production. Acidosis contributes to demineralization of bone and increased protein degradation, which may be associated with increased morbidity

Management:

• Supplementation with sodium bicarbonate may be considered in people with acidosis
• Increased sodium load may worsen blood pressure control