Clearance of large solute part 2

Newer high-flux dialyzer offer increased clearances for large molecular weight solutes, particularly when used in a therapy with convection, there may be a limit to the benefits that accrue from their use because of limitations imposed by intra-body mass transfer.When mass transfer in the body becomes limiting, changing treatment time and frequency will be more important than increasing clearance.

A recent development has been the introduction of protein-leaking membranes for hemodialysis.  These membranes allow the passage of larger molecules than do traditional high-flux membranes at the cost of some albumin loss. Preliminary clinical studies suggest that use of protein leaking membranes may aid in anemia correction, reduce hyperhomocysteinemia and reduce plasma concentrations of glycosylated and oxidized proteins.