Rupture of a dialyser membrane can occur due to :
- Dialyser being dropped
- Application of excessive trans-membrane pressure during isolation ultrafiltration of excessive fluid removal
- Clotting of the blood circuit
- Clotting of the dialyse
False alarms (which activate the machine alarm system as if it were a true blood leak), can be caused by tiny air bubbles passing through the intact membrane. This is generally caused by inadequate priming before dialysis has commenced on air which has entered the blood circuit during the treatment requiring "recirculating" until all air is removed and the alarm cleared
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