Azathioprine is a purine analog that inhibits the synthesis of adenosine and guanine. Like cyclophosphamide, it is converted to an active metabolite (6-mercaptopurine), which inhibits the division of activated B and T cells. Azathioprine is used in the treatment of RA, SLE, autoimmune hepatitis, inflammatory myopathy, vasculitis and other autoimmune disorders.
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