Turning first to examinations of CD4 T-cell immune responses in seronegative sex workers compared with HIV-positive women, CD4 T cells that produced interferon gamma (IFN-γ) in response to HIV p24 were detected in exposed seronegative sex worker (ESN) women, albeit at a much lower level than in HIV-positive women. However, ESN women had a 4.5-fold stronger CD4 proliferation response to the p24 peptide compared with the HIV positive group. These data suggest that CD4 T cells in ESN women recognize HIV and have an enhanced ability to proliferate to the p24 protein.
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