Another mouse model that develops features resembling human B-CLL involves the overexpression of two genes: BCL-2 and TRAFT2 (TNF-receptor-associated factor 2). This double transgenic animal is especially intriguing because of the already mentioned recent work showing that the deletion at 13q14, often see in human B-CLL, involves the loss of micro-RNAs 15a and 16-1, which affects expression of BCL2. As with the TCL1 transgenic mice, these animals develop CD5 B-cell clones, eventually with massive splenomegaly and leukemia.
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