An abundance of new information has become available within the past decade, such that B-CLL is now divided into two related conditions, both originating from antigen-selected B lymphocytes but differing in clinical course. Some patients lives several decades, often without treatment, and others succumb to the disease in a few years. Here we shall discuss the possible mechanisms causing expansion and conversion of normal B lymphocytes to leukemic clones and determining the differences between the two major B-CLL subtypes. First, we will review B-cell development and the aberrant transformation to leukemia.
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