ANIMAL MODELS OF B-CLL
While an enormous amount of new information has been gleaned by directly studying human B-CLL cells, animal models are now contributing to our understanding of the human disease. For example, New Zealand Black (NZB) mice spontaneously develop, with age, an expansion of IgMCD5 B cells that resembles B-CLL. However, because frank leukemia occurs randomly in only a minor subset of animals, this model has been used sparingly.
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