Basic components of the immune system part 163

The importance of innate immunity and the emergence of the toll-like receptors have led to the recognition that immune modifiers must be an essential component of any cancer vaccine. The inclusion of QS21, ISCOMS, Montanide, heat shock proteins, CpG,BCG, and granulocyte-macrophage colony-stimulating factor with cancer vaccines reflect this. Of interest in this respect are the anecdotal  success of Coley's toxin at the turn of the nineteenth  century ( a heat-killed mixture of streptococcal cells probably superantigen broths), which may now be reinterpreted in the light of the newly identified immune response modifiers.