The use of an antibody-coated target to destroy foreign target cells is called antibody-dependent cell-mediated cytotoxicity, or ADCC. This killing is dependent on the recognition by cells bearing Fc receptors and includes monocytes, neutrophils and NK cells. These cells do not need simultaneous recognition by MHC molecules. The mechanisms of killing most likely involve the release of cytoplasmic components of the target cells and perforin, but additional factors are also probably involved.
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