Several studies have focused on the distribution of these two alleles in women experiencing recurrent pregnancies loss. Expression of HLA-E at the feto-maternal interface may be implicated in the successful pregnancy because of its ability to downregulate maternal immune response. In the decidua, the area of the interface where feto-maternal interaction occurs, CD-56-positive natural killers cells are the dominant type of lymphocytes and express CD94:NKG2A complex, suggesting that HLA-E protein on the trophoblasts can be recognized by the maternal immune system. Evidence showing lower expression of HLA-ER, and its lower stability may impair its capability to downregulate natural killer cells and hence may be associated with recurrent pregnancies loss.
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