HAEMATOPOIETIC STEM CELL TRANSPLANT
The HLA system is the primary immunologic barrier to successful stem cell transplant. Therefore, the clinical outcomes of haematopoietic stem cell transplant are dependent on optimizing the histocompatibility matching between the patient and the donor. The HLA antigens are effectve stimulators and targets of graft versus host disease and graft rejection. HLA possess outstanding ability to elicit immune response either by presentation of variable peptides or by recognition of polymorphic fragments of foreign HLA molecules. In the future, evaluation before haematopoietic stem cell transplant is likely to comprise a more detailed genetic analysis of patient and donor, but currently the standars is HLA typing at A, B, C, DRB1 and DQB1 genetic loci.
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