The deviation include the complete absence or downregulation of HLA class I allo-specificities in frequent association to an impairment of a single or various members of the antigen-processing and antigen-presenting machinery. In most cases, it seems that the HLA class I abnormalities result from a deregulation rather than a structural defect suggesting an intervention at the epigenetic, transcriptional and or post transcriptional level. This observation increases even more the importance of studying the crosstalk between the tumour cells and the microenvirontment.
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