After 1998, when better HLA typing methods replaced DNA fingerprinting, serology and low resolution methods used for final donor matching the overall survival of transplant patients have improved greatly. Most studies now agree that HLA-DQB1 does not need to be considered in a well-matched donor, but there is evidence that there may be additive effects of a DQB1 mismatch, if a mistmatch at another locus is present. In certain circumstances (and particularly if more than one donor is available), typing for the HLA-DPB1 locus should be performed and the degree and the type of matching considered in donor selection.
No comments:
Post a Comment