During the era of donor-specific transfusion, patients were given blood from their prospective transplant donor, thypically three reduce volume transfusions during a period of 1-2 months. Under this protocols, many patients were transfused with blood from HLA-typed donors who had a variably degree of HLA match such as HLA-DR-matched transfusion. As expected, when more HLA antigens were matched, there was an independent association with a significantly decreased risk of sensitization.
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