HIV/AIDS
Human immunodeficiency virus and acquired immune deficiency syndrome (HIV/AIDS) is one of only a few infectious disease showing a clear-cut and consistent HLA association. The primary influence of HLA loci on the HIV disease relative to all other single human genetic variants has now been confirmed by several genomewide association studies. The data supported numerous genetic epidemiological studies reported previously, which had implicated many HLA alleles in various aspects of HIV disease. Thus, all the available evidence points to HLA as the most significant locus in differential control of HIV across humans.
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