HLA and transplantation
In addition to situations in which a malfunction of the HLA system occurs, problems can arise when it functions too well. This is the case when one attempts to transplant tissues or organ between genetically disparate individuals of the same or different species (allografts and xenografts, respectively). The T cell receptors of the recipient's lympocytes recognize either the donor's (allogeneic) HLA molecules on the antigen presenting cell of the graft (a process known as direct presentation) or the donor's HLA molecules on antigen presenting cell of the recipient (a process known as indirect presentation). During indirect presentation, the peptides are generated by degradation of the allogeneic HLA molecules released from the graft,
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