Depending on the nature of the antigen (endogenous or exogenous), the MHC response is different. For example, endogenous antigens (including viral antigens) are presented by MHC class I antigen cells exclusively CD8 cells. The endogenous antigen is first broken down into small peptides and transported by shuttle proteins called Tap I and Tap II to the endoplasmic reticulum. There they complex with MHC class I molecules and are delivered to the cell surface for further processing to the CD8 cells.
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