Two other classes are worthy of note. IgD is synthesized by antigen-sensitive B cells and is involved in the activation of these cells by antigen. Ig E is produced by plasma cells and binds to specific IgE receptors on mast cells and basophiles. This molecule play an extremely important role in allergic reactions and expelling intestinal parasites, which is accomplished by increasing vascular permaeability and inducing chemotactive factors following mast cell degranulation.
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