The critical step in complement activation is the cleavage of the C3 component by complement-derived enzymes called C3 convertases. This result in the presence of C3b, which mediates a number of vital biological activities. The cleavage of C3b can be initiated by three routes (classical, alternative and lectin), but each route is in response to different stimuli. Individuals who are deficient in C3 are obviously predisposed to bacterial infections and immune complex disease.
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