HLA system in solid organ transplantation part 34

Transplantation was regarded as the most significant breakthrough in immunology and medicine in the last century. With no doubt, deciphering transplantation tolerance and achieving it reliably in the clinical setting would be of a greater impact to humankind. The differences between the HLA molecules of donors and recipients are the initial trigger to allostimulate the immune system of the recipient, and those differences are to persist for the entire life of the transplant, simply escalating the alloresponese and aggravating tissue injury. Until the advent of targeted specific immunotherapies or tolerogenic protocols, we shall aim to ensure the best possible histocompatibility between the donor and the recipient, and to conceptualise and utilise HLA matching from a less conventional perspective.