Transplant patients have to receive immunosuppresive drugs to subjugate the immune system so as to avoid transplant rejection. However, immunosuppressive drugs, although to a certain extent are effective in reducing rejection rates and in prolonging transplant survival, come with a constellation of toxic effects and have not actually been proven to induce immune tolerance. It appears that a detailed dissection of the immunogenicity of transplant organs is a crucial step for the improvement of current immunodiagnostic tools and the design of a more targeted and effective armamentarium to prevent and combat transplant rejection.
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