In kidney transplantation, current criteria for HLA matching consider three loci: HLA-A, HLA-B and HLA-DR. Each allele is defined as a single antigen assigned by serologic typing criteria (eg HLA-A1, HLA-B44, HLA-DR7). Each donor and recipient can type for up to six different HLA antigens encoded by these loci, and HLA compatibility is usually assessed by the number of HLA mismatches (or matches) of the donor. Many studies has shown a stepwise decrease in graft survival of cadaver kidneys with increasing numbers of HLA mismatches. The superior results with zero HLA-A, HLA-B and HLA-DR mismacthes have led to a system of mandatory sharing of such donor kidneys.
No comments:
Post a Comment