Histocompatibility in organ transplant
HLA matching clearly improves the survival of transplanted kidneys, hearts, and lungs, but HLA-based donor organ allocation has been implemented only for kidney transplantation. This system considers ABO and HLA compatibility of the donor and the results of the lymphocytotoxicity crossmatch test between patient serum and donor cells. Time constraints on the preservation of donor hearts and lungs do not permit prospective HLA matching for these organs. In some instances, crossmatching is done for cardiothoracic transplantation, especially if the patient is HLA sensitized.
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